Proton spectroscopy of the corpus callosum in healthy controls: Detecting microstructural differences along the mid-sagittal length
Wilkinson I, Wignall E, Greenwood P, Griffiths P
University of Sheffield
It is known from histological studies that both axonal density and type vary within the corpus collosum. This work sought to determine whether there are differences on localised proton spectroscopy between the anterior and posterior aspects of the normal corpus collosum. A long echo time (135ms) single-voxel PRESS technique acquired spectra from 10 healthy males. Significant differences in NAA/Cho and NAA/Cr were found between the 2 anatomical locations. Proton spectroscopy shows biochemical differences along the body of the corpus collosum.