Evaluation of Intra-Renal Oxygenation During Water Diuresis: A Time Resolved Study Using BOLD MRI
Tumkur S, Vu A, Li L, Prasad P
Evanston Northwestern Healthcare, Northwestern University
BOLD MRI applied to the kidney has been shown to be useful in the functional evaluation of healthy and diseased states. Preliminary results using a 3-D mGRE sequence at 3.0T and 1.5T to evaluate intra-renal oxygenation changes following administration of furosemide has demonstrated great promise. Following a pharmacological maneuver, the 3-D mGRE sequence permitted the examination of a temporal BOLD response within the renal medulla without sacrificing spatial coverage. In this study, we evaluated the feasibility of using the 3-D mGRE sequence at 3.0T for following temporal responses during water loading. The waterload protocol was performed with and also without cyclooxygenase inhibition by naproxen in order to evaluate the influence of prostaglandins on the observed response.