Abstract #3412

Trivedi R, Malik G, Gupta R, Hasan K, Hasan M, Gupta A, Pandey C, Narayana P

Serial diffusion tensor imaging (DTI) at two-time points (at birth and at three months) was performed in term neonates with hypoxic-ischemic encephalopathy (HIE) and healthy controls to quantify the white matter abnormalities. On comparing fractional anisotropy (FA) and mean diffusivity (MD) change over time, we observed significant reduction in age related FA increase in periventricular white matter in HIE children where as significant reduction in age related MD decrease in HIE children was observed in deep gray matter region as compared to healthy control. These abnormalities in diffusion tensor imaging (DTI) matrix suggest difference in gray and white matter maturation in neonates with hypoxic-ischemic injury.