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Abstract #3452

Voxel Based Analysis of ADC, FA and Hemispheric Asymmetry in Normal Aging

Ardekani S, Sinha U

Age related microstructural changes in brain white matter (WM) could be studied utilizing DTI. We examined alterations in FA and ADC employing voxel and ROI based analysis. A non-linear registration algorithm was used to align subject image volumes to a common template. The results showed significant age related decline in FA in frontal WM, genu and body of corpus callosum, posterior limb of internal capsule and anterior and posterior limbs of external capsule. Regional hemispheric asymmetry in FA and ADC showed decrease in asymmetry with age. The voxel based findings were confirmed by ROI based analysis.