Age Related Cognitive Decline and White Matter Changes Studied by Diffusion MRI
Sasson-Sarig E, Doniger G, Assaf Y
Tel Aviv University
Normal aging is accompanied by pathologies that affect cognitive abilities of the elderly population. Imaging studies found age related white matter (WM) changes in the frontal lobe. WM of young and old subjects was investigated using q-space imaging (QSI) and DTI, correlated with their cognitive performance. The results showed higher q-space displacement and reduced FA in frontal WM, related to age and cognitive performance. It was concluded that structural pathophysiological alternations in WM can be related to age and cognitive performance using DTI and QSI, with a larger effect revealed by QSI.