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Abstract #3463

Improved sensitivity in the temporal lobe epilepsy by measuring the area and volume of the diffusion anisotropy tensor

Wang J, Yang C, Lu Y, Wai Y, Chyi T
ChangGung University

A reduced Fractional Anisotropy and increase trace were often noticed as an indication of the change of the micro-structure in Epilepsy. To improve the CNR and sensitivity of the diffusion anisotropy index on Epilepsy studies, we performed a systematic analysis by comparing the measures of the amplitude, area and volume on the normalized diffusion deviation tensor. The result shows that the measures of area and volume have improved sensitivity and better delineation of the lesion than the corresponding FA. The diffusion anisotropy index is more specific to the detection of seizure compared with trace.