Assessing white matter abnormalities in HIV patients using diffusion tensor imaging statistics through elastic image registration
Lin W, An H, Bullitt E, Smith J, Robertson K, Hall C, Chen Y, Kwock L, Wilber K, Robertson W
The Univ. of North Carolina at Chapel Hill
Diffusion tenor imaging has been demonstrated capable of delineating white matter abnormalities in neurodegenerative diseases. However, it is unclear whether or not DTI will be able to delineate the severity of HIV. We have employed spatially normalized DTI statistics in evaluating the three different clinical stages of HIV patients and results suggest that the statistically detected DTI abnormalities could be a potential biomarker for the severity of HIV disease.