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Abstract #3519

Ultrastructural Characteristics of Feridex Endocytosis by Human Peripheral Mononuclear Cells and Mesenchymal Stem Cells

Moore A, Pratt J, Sorensen A
Massachusetts General Hospital

In this study, unique findings regarding the agglomeration state of internalized Feridex were observed in both PBMCs and HMSCs using transmission electron microscopy. In both PBMC monocytes and HMSCs, linear bands of sequestered Feridex nanoparticles were observed at the cell surface. The high concentrations of internalized bands of Feridex ranging from 0.5 - 2 microns suggest that the magnetic properties of Feridex in intracellular compartments are vastly different from ferumoxides suspended in solution.