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Abstract #3520

Targeting of Membrane Type1-Matrix Metalloproteinase (MT1-MMP) by using ultrasmall superparamagnetic iron oxide (USPIO) particles to hepatocellular carcinoma cells in vivo

Jung J, Lee Y, Song H, Woo S, Chang Y, Park J, Park B, Kim J
Kyungpook National University

Membrane-type 1 matrix metalloproteinase (MT1-MMP) has been implicated in various physiological and pathological processes. Especially, MT1-MMP is highly expressed in different cancers, and overexpression promotes migration, invasion and metastasis of cancer cells in vitro as well as in vivo. In this study, we investigate tumor specificity of MT1-MMP at molecular biology level and examine the possibility of MT1-MMP as a tumor marker using conjugation of streptavidinylated USPIO and biotinylated monoclonal antibody (mAb) MT1-MMP in MRI.