Quantitative assessment of subendocardial perfusion abnormality in hypertrophic cardiomyopathy: Correlation with myocardial scar.
Kitagawa K, Kurita T, Nakano T, Ishida M, Onishi K, Sakuma H, Takeda K
Mie University School of Medicine
Transmural distribution of myocardial blood flow was determined in nine patients with HCM by using Patlak plot analysis of stress-rest perfusion MRI. In HCM patients, the endo/epi flow ratio significantly decreased to 0.92 +/- 0.14 during stress compared to resting state (0.99 +/- 0.13, p<0.001). In segments exhibiting delayed hyperenhancement, the endo/epi ratio was reduced in comparison with the segments without delayed hyperenhancement both in the resting state and during vasodilator stress, indicating close relationship between scar formation and subendocardial perfusion abnormality in patients with HCM.