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Abstract #3612

Improved Cardiac Tagging Resolution at 14.1 T Enables Principal Strain Measurements in the LV Wall of a Mouse Model of Regional Dilated Cardiomyopathy

Hankiewicz J, Lewandowski E
University of Illinois at Chicago, College of Medicine

Changes in the principle strains (E1 and E2) in the LV wall were examined by combined high resolution DANTE tagging (0.45 mm line spacing and 0.1 mm line thickness) and fast gradient echo imaging at 14.1 T in a transgenic mouse model of pure, dilated cardiomyopathy, in which protein kinase C epsilon is overexpressed. The principle E1 strain is reduced in regions of LV wall thinning associated with the development of LV dilation. The findings demonstrate changes in E1 in the LV of the transgenic mouse model, of progressive ventricular dilatation, predate eventual transitioning to heart failure.