Abstract #3618

Graham B, Dardzinski B, Workie D

Longitudinal study on 17 subjects with juvenile rheumatoid arthritis (JRA) was performed at three time points: enrollment, 3 months, and 12 months. The longitudinal studies included quantitative DCE-MRI, clinical and laboratory assessments. When compared to the enrollment values, all pharmacokinetic (PK) parameters, clinical and laboratory measures at 3 months and 12 months showed a significant decrease, except for the CHAQ-DI and CRP at 3 months. In most comparisons, the average PK values showed excellent correlation with clinical and laboratory assessments. The decrease of PK parameters might reflect diminution of disease activity and could be used as an objective follow-up of JRA patients.