Lorenzo Mannelli1, Andrew N. Priest1, Martin J. Graves1, Ilse Joubert1, Li Tee Tan2, Robin Crawford3, James Brenton2,4, David J. Lomas1, Evis Sala1
1Radiology, Addenbrooke's Hospital and University of Cambridge, Cambridge, UK; 2Oncology, Addenbrooke's Hospital and University of Cambridge, Cambridge, UK; 3Obstetrics & Gynaecology, Addenbrooke's Hospital and University of Cambridge, Cambridge, UK; 4Cambridge Research Institute, Cancer Research UK, Cambridge, UK
Radiotherapy is usually effective in cervix cancer treatment. Imaging techniques that can predict treatment outcome would allow further treatment individualisation. There is a current lack of standardised and independently validated analysis of quantitative DCE-MRI parameters. Subtraction imaging is easy, widely available and it overcomes protocols variability. The pre-treatment percentage of non enhancing tumour was visually assessed in 13 patients using subtracted images. The tumour volume regression from pre-treatment to post-treatment was calculated. A strong correlation (r = -0.821; p < 0.001) was found between the pre-treatment percentage of non-enhancing tumour and the percentage of tumour volume regression.