Abstract #0086

Tumour Necrosis Assessed by Magnetic Resonance Dynamic Contrast-Enhanced Subtraction Imaging Is a Predictor of Chemoradiotherapy Response in Advanced Cervical Cancer

Lorenzo Mannelli¹, Andrew N. Priest¹, Martin J. Graves¹, Ilse Joubert¹, Li Tee Tan², Robin Crawford³, James Brenton^2,4, David J. Lomas¹, Evis Sala¹

¹Radiology, Addenbrooke's Hospital and University of Cambridge, Cambridge, UK; ²Oncology, Addenbrooke's Hospital and University of Cambridge, Cambridge, UK; ³Obstetrics & Gynaecology, Addenbrooke's Hospital and University of Cambridge, Cambridge, UK; ⁴Cambridge Research Institute, Cancer Research UK, Cambridge, UK

Radiotherapy is usually effective in cervix cancer treatment. Imaging techniques that can predict treatment outcome would allow further treatment individualisation. There is a current lack of standardised and independently validated analysis of quantitative DCE-MRI parameters. Subtraction imaging is easy, widely available and it overcomes protocols variability. The pre-treatment percentage of non enhancing tumour was visually assessed in 13 patients using subtracted images. The tumour volume regression from pre-treatment to post-treatment was calculated. A strong correlation (r = -0.821; p < 0.001) was found between the pre-treatment percentage of non-enhancing tumour and the percentage of tumour volume regression.