Jaap Hoogendam1, Wenche Margrethe Klerkx2, Gerard de Kort1, Ronald Zweemer1, Willem Mali1, Wouter Veldhuis1
1University Medical Center Utrecht; 2Radiology, University Medical Center Utrecht, Utrecht, Netherlands
In diffusion weighted imaging a variety of b-value combinations is used to calculate apparent diffusion coefficients (ADC) for malignancy discrimination. We scanned 35 patients with cervical cancer at 3T and investigated three b-value combinations used in the literature (b=0,1000 vs 0,150,500,1000 vs 150,500,1000 s/mm2) for their influence on ADC and the ability to identify cervical malignancies. Results show a significantly lower ADC in cervical malignancies compared to benign cervical tissue. A high sensitivity and specificity (all over 90%) was found at all optimal ADC cut-off values, independent of the b-value combination used to calculate ADC.