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Abstract #0135

High Resolution 31P Magnetic Resonance Spectroscopic Imaging with Polarization Transfer of Phosphomono and -Diesters in the Human Brain at 3T

Jannie Petra Wijnen1, Tom W.J. Scheenen1, Arend Heerschap1

1Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands

(Glycero)phosphocholine and (glycero)phosphoetanolamine are important substances in membrane metabolism, and can be detected in the brain by 31P MRS. We have developed a spectroscopic imaging sequence with efficient 1H to 31P polarisation transfer, optimized for the signals of PE, PC, GPE and GPC by using chemical shift selective refocusing pulses. Here we present the first results of the ratios of these compounds in the cerebellum, white matter and gray matter of the normal human brain at different ages.