Jullie W. Pan1,2, Nikolai Avdievich1, Dennis Spencer1, Hoby P. Hetherington1,3
1Neurosurgery, Yale University School of Medicine, New Haven, CT, USA; 2BME, Yale University School of Medicine, New Haven, CT, USA; 3Radiology, Yale University School of Medicine, New Haven, CT, USA
As a functional measure of bioenergetic state in human brain, 31P MRS is sensitive to effects of relaxation, concentration and chemical exchange. While the sensitivity to creatine kinase has been well used in muscle spectroscopy with saturation transfer experiments it has been less developed for brain. Given that creatine kinase rates have demonstrated sensitivity to physiologic condition it may be informative for pathologic state. We implemented exchange sensitive weighting to the 31P spectroscopic imaging acquisition, parameters based on 3site exchange simulations to ascertain sensitivity to varying levels of exchange. We demonstrate this approach in controls and epilepsy patients at 7T.
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