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Abstract #0150

Voxel Based Morphometric Analysis of the Gbx2 Mutant Mouse Phenotype via MEMRI

Kamila Urszula Szulc1,2, Brian J. Nieman1,2, Roy V. Sillitoe3, Alex L. Joyner3, Daniel H. Turnbull1,2

1Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, NYU School of Medicine, New York, NY, USA; 2Radiology, NYU School of Medicine, New York, NY, USA; 3Developmental Biology, Sloan-Kettering Institute, NY, New York, NY, USA

The cerebellum (Cb) is a highly patterned brain structure with a stereotypical foliation pattern playing an essential role in normal motor and cognitive function. Previously we demonstrated the feasibility of in vivo longitudinal MEMRI of Cb development in normal and Gbx2-CKO mice during critical neonatal stages of foliation, including volumetric analysis of the vermis deletion and abnormalities in the flocculus-paraflocculus complex and deep cerebellar nuclei that were not previously reported. In the current study, we extended our analysis to whole brain deformation-based morphometry in order to provide a comprehensive, unbiased characterization of the Gbx2-CKO phenotype.