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Abstract #0204

Hepatic Fat Quantification in Children Using Multi-Echo Gradient-Echo Imaging and Fat Spectral Modeling at 1.5 T

Masoud Shiehmorteza1, Takeshi Yokoo1, Gavin Hamilton1, Mark Bydder1, Manuel Rodriguez1, Joel E. Lavine2, Jeffrey B. Schwimmer2, Claude B. Sirlin1

1Radiology, University of California San Diego, San Diego, CA, USA; 2Pediatrics, University of California San Diego, San Diego, CA, USA

Fatty liver disease is currently the most common cause of liver disease in children (12-17% prevalence). Although MR imaging has been applied to children previously, the accuracy of fat quantification has not been verified. Confirming that MR imaging is accurate in children is necessary because they may not be able or willing to cooperate with MR examinations. Also, the histological features of pediatric FLD differ from those of adult FLD, and generalization of adult studys data may not be valid. In this dedicated pediatric study, we assessed fat estimation accuracy of MR imaging, using single-voxel MR spectroscopy as the reference.