Abstract #0207

Validation of Chemical Shift Based Fat-Fraction Imaging with MR Spectroscopy

Sina Meisamy¹, Catherine DG Hines^1,2, Gavin Hamilton³, Karl Vigen¹, Jean H. Brittain⁴, Charles A. McKenzie⁵, Huanzhou Yu⁶, Scott K. Nagle¹, Yu Grace Zeng¹, Claude B. Sirlin³, Scott B. Reeder^1,2

¹Radiology, University of Wisconsin, Madison, WI, USA; ²Biomedical Engineering, University of Wisconsin, Madison, WI, USA; ³Liver Imaging Group, Department of Radiology, University of California, San Diego, CA, USA; ⁴Applied Science Laboratory, GE Healthcare, Madison, WI, USA; ⁵Medical Biophysics, University of Western Ontario, London, Ontario, Canada; ⁶Applied Science Laboratory, GE Healthcare, Menlo Park, CA, USA

Nonalcoholic steatohepatitis is a form of liver disease, which affects nearly 30% of the US population and 75% of obese individuals. 1H-MRS is regarded by many as the non-invasive gold standard for quantification of hepatic steatosis. In this study we compare a chemical shift based fat-fraction imaging method (IDEAL) of the liver with 1H-MRS for quantification of hepatic steatosis. The results of our study show that overall, there is excellent correlation between IDEAL and MR spectroscopy with the highest correlation and excellent one-one agreement seen when both T2* correction and accurate spectral modeling of fat is applied.