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Abstract #0207

Validation of Chemical Shift Based Fat-Fraction Imaging with MR Spectroscopy

Sina Meisamy1, Catherine DG Hines1,2, Gavin Hamilton3, Karl Vigen1, Jean H. Brittain4, Charles A. McKenzie5, Huanzhou Yu6, Scott K. Nagle1, Yu Grace Zeng1, Claude B. Sirlin3, Scott B. Reeder1,2

1Radiology, University of Wisconsin, Madison, WI, USA; 2Biomedical Engineering, University of Wisconsin, Madison, WI, USA; 3Liver Imaging Group, Department of Radiology, University of California, San Diego, CA, USA; 4Applied Science Laboratory, GE Healthcare, Madison, WI, USA; 5Medical Biophysics, University of Western Ontario, London, Ontario, Canada; 6Applied Science Laboratory, GE Healthcare, Menlo Park, CA, USA

Nonalcoholic steatohepatitis is a form of liver disease, which affects nearly 30% of the US population and 75% of obese individuals. 1H-MRS is regarded by many as the non-invasive gold standard for quantification of hepatic steatosis. In this study we compare a chemical shift based fat-fraction imaging method (IDEAL) of the liver with 1H-MRS for quantification of hepatic steatosis. The results of our study show that overall, there is excellent correlation between IDEAL and MR spectroscopy with the highest correlation and excellent one-one agreement seen when both T2* correction and accurate spectral modeling of fat is applied.