Abstract #0225

MR Imaging of an Arachidonic Acid-Induced Mouse Model of Thrombosis Using an Activated Platelets-Targeted Paramagnetic Contrast Agent.

Ahmed Klink^1,2, Eric Lancelot³, Sbastien Ballet³, Walter Gonzalez³, Christelle Medina³, Claire Corot³, Jean-Etienne Fabre⁴, Willem J.M Mulder¹, Ziad Mallat², Zahi A. Fayad¹

¹Translational and Molecular Imaging Institute, Mount Sinai School Of Medicine, New York, NY, USA; ²INSERM U689, Paris, France; ³Research Division, Guerbet, France; ⁴Atherothrombosis Laboratory, Institut de Gntique et de Biologie Molculaire et Cellulaire, Strasbourg, France

P975 is a paramagnetic MRI based contrast agent with specificity for activated platelets via a peptide that binds to the glycoprotein GPIIb/IIIa. This agent was used in an arachidonic acid-induced mouse model of thrombosis to visualize thrombi formation and monitor thrombogenic activity.