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Abstract #0226

in Vivo CEST Imaging Using Eu(III)-Water Molecule Exchange System

Tomoyasu Mani1,2, Osamu Togao1, Todd C. Soesbe1, Masaya Takahashi1, Allan Dean Sherry1,2

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA; 2Department of Chemistry, University of Texas at Dallas, Richardson, TX, USA

Chemical exchange saturation transfer (CEST) imaging has attracted considerable attention. Ln(III)-based exogenous CEST agents (PARACEST) can be used to enhance the sensitivity of CEST imaging. As part of a program to develop more effective agents, a newly designed Eu(III)-DOTA-tetraamide complex was applied in vivo. The CEST effect from this agent were somewhat smaller when the agent was dissolved in blood plasma at body temperatures (35-39 C) compared to when it was dissolved in pure water. No differences in CEST were observed at lower temperatures (20-27 C). CEST contrast in liver and kidney of mouse (20%) were successfully observed using low presaturation pulse (7T) to avoid competitive inherent MT effects.