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Abstract #0235

Simultaneous Quantitation of T2 and Concentration of Vitamin C and GSH in the Human Brain in Vivo Using Multiple Echo Time Double Editing with MEGA-PRESS at 4 and 7 T

Uzay Emir1, Malgorzata Marjanska1, Dinesh Deelchand1, Pierre-Gilles Henry1, Ivan Tkac1, Melissa Terpstra1

1University of Minnesota, Minneapolis, MN, USA

Double Edited MEGA-PRESS spectra were detected at multiple TE in the human brain to measure T2 of Asc and GSH. Data from 22 subjects studied at 4 T were pooled to measure a 50 ms T2 for GSH (95% CI 41-62). The Asc T2 was not determined due to contamination by co-edited resonances. To our knowledge, this is the first time the T2 of GSH has been reported. Spectra measured at several TE in the human brain at 7 T suggest that this methodology can be utilized to measure the Asc and GSH T2 at 7 T.