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Abstract #0237

GABA Concentration in Visual Cortex Correlates with Individual Differences in γ-Band Oscillation Frequency

Richard A. Edden1, Suresh Daniel Muthukumaraswarmy2, Derek K. Jones2, Jennifer B. Swettenham2, Krish D. Singh2

1Schools of Chemistry and Biosciences, Cardiff University, Cardiff, Wales, UK; 2CUBRIC, School of Psychology, Cardiff University, Cardiff, Wales, UK

GABA, the principle inhibitory neurotransmitter in the human CNS, plays an important role in the neuronal processes of the healthy brain, and altered GABAergic neurotransmission has been implicated in pathologies from epilepsy to bipolar disorder. This study presents a novel combination of edited MRS measurements of GABA with functional measurements of brain activity by magnetoencephalography and shows a strong correlation between GABA and γ-band oscillation frequency.