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Abstract #0250

White Matter Microstructure Abnormality in Autism Spectrum Disorders : A DTI Based Subdivided Corpus Callosum Study

Pei-Chin Chen1, Kun-Hsien Chou2, I-Yun Chen3, Chun-Yi Lo1, Hsuan-Hui Wang1, Ya-Wei Cheng3, Ching-Po Lin1,3

1Institute of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan; 2Institute of Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan; 3Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan

Autism spectrum disorders (ASD) is a heterogeneously neurodevelopmental disorder, that is characterized by impaired social reciprocity, communication difficulties, and restricted interest. To observe the abnormal brain connectivity in ASD, the investigation of subdivision corpus callosum using DTI fiber tracking with fractional anisotropy (FA), can indicate the integrity of the fiber tracts. The ASD had greater FA in the Region 4 and 5 than healthy subject, the result indicated that the communication between bilateral hemispheres was abnormal in motor, somaesthetic areas. Previous studies indicated abnormal regulation of brain growth in ASD results from early overgrowth followed by abnormally slowed growth.