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Abstract #0355

Effect of Short- And Long-Term Type 1 Diabetes on the Neurochemical Profile in STZ-Induced Diabetic Rats at 9.4 T

Wen-Tung Wang1, Sang-Pil Lee2,3, Irina Smirnova4, In-Young Choi1,5

1Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, USA; 21Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, USA; 32Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA; 4Department of Physical Therapy and Rehabilitation Sciences, University of Kansas Medical Center, Kansas City, KS, USA; 52Department of Neurology, Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA


The neurological consequences of diabetes mellitus were assessed during short- and long-term streptozotocin-induced diabetes in the rat brain. Early yet subtle changes of neurochemical contents in the streptozotocin(STZ)-induced diabetes were detected using in vivo ultra-short echo time 1H MRS at 9.4 T. Acute hyperglycemia led to significant changes in alanine, -hydroxybutyrate, glutamine, myo-inositol, lactate, taurine, and choline compounds (GPC+PCho). While glutamine showed a transient increase during the short-term hyperglycemic period, others maintained persistent changes through the chronic stage. Four weeks after the STZ-injection, aspartate, glutathione and N-acetylaspartate started to show significant decreases, indicating increased oxidative stress and neuronal loss during the disease progression.