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Abstract #0357

Orientationally Invariant Axon-Size and Density Weighted MRI

Daniel C. Alexander1, Penny L. Hubbard2, Matt G. Hall1, Elizabeth A. Moore3, Maurice Ptito4, Geoff J. M. Parker2, Tim B. Dyrby5

1Centre for Medical Image Computing, Dept. Computer Science, UCL (University College London), London, UK; 2Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, University of Manchester, Manchester, UK; 3Best, Philips Healthcare, Eindhoven, Netherlands; 4School of Optometry, University of Montreal, Montreal, Canada; 5Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Copenhagen, Denmark

We present a diffusion MRI technique for mapping correlates of the axon size and density in white matter over the whole brain. Unlike previous techniques, the method does not require prior knowledge of the fibre direction. Results from a perfusion fixated monkey brain agree with histological data in the literature. Further results from in vivo human brain data, acquired in less than one hour on a standard system, also show the expected trends.