Abstract #0415

Combining DCE-MRI and Microbubble Ultrasound to Evaluate Response to Sunitinib in Patients with Renal Cell Carcinoma

Colleen Bailey^1,2, Ross Williams², Gord Lueck², Mostafa Atri³, Peter N. Burns^1,2, Greg J. Stanisz^1,2, Georg A. Bjarnason⁴

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada; ²Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; ³Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; ⁴Medical Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Patients with renal cell carcinoma were treated with the drug Sunitinib and examined by DCE-MRI and contrast-enhanced ultrasound. DCE-MRI provided the volume transfer constant, K_trans, and the extravascular extracellular volume fraction v_e. Disruption-replenishment provided the relative blood volume change. Combining the information from both imaging techniques provides a fuller picture of the tumour response to treatment.