Abstract #0416

Potential of Choline SNR, Tumor Volume and Diameter in the Assessment of Response of Locally Advanced Breast Cancer Patients Using Sequential MRSI and MRI

Karikanni Kalathil A. Danishad¹, Uma Sharma¹, Rani Gupta Sah¹, Vurthaluru Seenu², Rajinder Parshad², Naranamangalam R. Jagannathan¹

¹Department of NMR and MRI Facility, All India Institute of Medcial Sciences, New Delhi, Delhi, India; ²Department of Sugical Disciplines, All India Institute of Medcial Sciences, New Delhi, Delhi, India

Sequential MRSI [before therapy and after I, II and neo-adjuvant chemotherapy (NACT)] was carried out in 30 breast cancer patients to evaluate the potential of signal-to-noise ratio of choline (ChoSNR), tumor volume and diameter to predict tumor response. Changes in these parameters revealed significant decrease in ChoSNR after I NACT compared to pre-therapy in responders than non-responders. Sensitivity to detect responders using ChoSNR was 85.7% with 91% specificity while 100% sensitivity for volume and diameter but with reduced specificity (73% and 81.8%). When all the three parameters were combined, 100%sensitivity, 82% specificity with 87.5% PPV and 100% NPV was achieved.