Karikanni Kalathil A. Danishad1, Uma Sharma1, Rani Gupta Sah1, Vurthaluru Seenu2, Rajinder Parshad2, Naranamangalam R. Jagannathan1
1Department of NMR and MRI Facility, All India Institute of Medcial Sciences, New Delhi, Delhi, India; 2Department of Sugical Disciplines, All India Institute of Medcial Sciences, New Delhi, Delhi, India
Sequential MRSI [before therapy and after I, II and neo-adjuvant chemotherapy (NACT)] was carried out in 30 breast cancer patients to evaluate the potential of signal-to-noise ratio of choline (ChoSNR), tumor volume and diameter to predict tumor response. Changes in these parameters revealed significant decrease in ChoSNR after I NACT compared to pre-therapy in responders than non-responders. Sensitivity to detect responders using ChoSNR was 85.7% with 91% specificity while 100% sensitivity for volume and diameter but with reduced specificity (73% and 81.8%). When all the three parameters were combined, 100%sensitivity, 82% specificity with 87.5% PPV and 100% NPV was achieved.