Abstract #0424

Non-Invasive Assessment of Transstenotic Pressure Gradients Utilizing 3D Phase Contrast MRA: Validation Against Endovascular Pressure Measurements in a Porcine Study

Thorsten Alexander Bley¹, Kevin M. Johnson², Oliver Wieben², Christopher J. Francois¹, Scott B. Reeder¹, Mark L. Schiebler¹, Darren P. Lum¹, Thomas M. Grist¹

¹Radiology, University of Wisconsin - Madison, Madison, WI, USA; ²Radiology and Medical Physics, University of Wisconsin - Madison, Madison, WI, USA

This study evaluates noninvasive assessment of transstenotic pressure gradients (TSPG) utilizing phase contrast with vastly under sampled isotropic projection reconstruction (PC VIPR) MRA for quantification of renal artery stenosis (RAS) in a porcine model. TSPG over surgically created bilateral RAS in 11 swine were compared to invasive endovascular pressure measurements obtained with pressure sensing guidewires. Excellent correlation of TSPG assessed with PC VIPR and the gold standard were found (Pearson correlation coefficient of 0.977), indicating the feasibility of this novel method for noninvasive assessment of the hemodynamic severity of RAS.