Panagiotis G. Kyrtatos*1,2, Michael R. Loebinger*3, Anthony N. Price1, Mathew Kallumadil4,5, Paul Southern4,6, Quentin A. Pankhurst4,6, Sam M. Janes3, Mark F. Lythgoe2,7
1Centre for Advanced Biomedical Imaging , UCL Institute of Child Health and UCL Department of Medicine, London, UK; 2RCS Unit of Biophysics, UCL Institute of Child Health, London, UK; 3Centre for Respiratory Research, University College London; 4London Centre for Nanotechnology; 5Davy-Faraday Research Laboratories, The Royal Institution of Great Britain, London, UK, *equal contribution to this work; 6Davy-Faraday Research Laboratories, The Royal Institution of Great Britain, London, UK, *equal contribution to this work; 7Centre for Advanced Biomedical Imaging, UCL Institute of Child Health and UCL Department of Medicine, London, UK
Lung cancer is the biggest cancer killer. Recent evidence suggests that stromal tissue within cancers can be mesenchymal stem cell (MSC) derived. Superparamagnetic iron oxide nanoparticles (SPIO) offer attractive possibilities in biomedicine as they can be utilized for MR imaging and targeted localized hyperthermia by application of RF magnetic field. The long term aim of our study is to utilize the tumor-homing capacity of MSCs to deliver a payload of nanoparticles for targeted hyperthermia and non-invasive MR monitoring of therapy. Here we present preliminary data on particle heating using a custom-made RF applicator, MSC labeling and tumor imaging.
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