Meeting Banner
Abstract #0453

Feasibility of in Vivo Metabolites Diffusion Tensor Assessment

Nicolas Kunz1,2, Stphane Sizonenko2, Rolf Gruetter1,3

1Laboratory of functional and metabolic imaging (LIFMET), Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 2Division of Child Growth & Development, Dept. of Pediatrics, University of Geneva, Geneva, Switzerland; 3Department of Radiology, University of Lausanne and Geneva, Switzerland

DTI is based on water molecules diffusion motion, which is present in both intra- and extra-cellular spaces. On the other hand, DW-MRS uses metabolites as diffusion markers by combining MRS with diffusion weighting technique and provides information limited to the intra-cellular compartment. In this study, DW-MRS shows that the principal diffusion directions of the metabolites were aligned to the water along the corpus callosum fibers, and is likely to shed light on the nature of the diffusion signal.