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Abstract #0455

Comparison of DTI Fiber Tracks with Light Microscopy of Myelinated Fibers

Ann Sunah Choe1,2, Xin Hong1,2, Daniel Christopher Colvin1,2, Iwona Stepniewska3, Zhaohua Ding1,2, Adam W. Anderson1,2

1Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA; 2Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA; 3Department of Psychology, Vanderbilt University, Nashville, TN, USA

Fibers tracked using Diffusion Tensor Imaging (DTI) are directly compared with myelin stained fibers on a microscopic level. Gold standard measurements of fiber orientation and spread from micrographs enabled us to investigate the challenges of DTI fiber tracking in brain tissue. Limitations due to partial volume averaging and image noise are readily observed.