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Abstract #0469

13C MRS Shows Altered Cerebral Glucose Metabolism During Acute Mild Hypoglycemia in Humans

Kim van de Ven1, Marinette van der Graaf1, Bastiaan de Galan2, Cees Tack2, Arend Heerschap1

1Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 2General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

Cerebral glucose metabolism was assessed by 13C-MRS under euglycemic (5.16 mmol/l) or hypoglycemic (2.95 mmol/l) conditions in 8 human volunteers during 2-hour hyperinsulinemic glucose clamps. Using 13C-1-glucose 20% solutions a stable plasma glucose 13C-enrichment was achieved, resulting in high SNR spectra. MRS-measurements were conducted with a 13C/1H volume head coil, and an ISIS-DEPT pulse sequence at 3T. Under hypoglycemic conditions, 13C signals of Asp3 and Glu2 reached a higher level, while Asp2 and Glu3 (and also Glu4) reached a lower level compared to euglycemic conditions This indicates altered cerebral glucose metabolism during mild hypoglycemia, possibly reflecting upregulated anaplerosis.