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Abstract #0492

Following the Development of Corpus Callosum (CC) in the Prenatal Period in Humans Through Diffusion Tensor Tractography (DTT)

Richa Trivedi1, Sona Saksena1, Shruti Agarwal2, Nuzhat Husain3, Ram K S Rathore2, Rakesh K. Gupta1

1Department of Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 2Department of Mathematics and Statistics, Indian Institute of Technology, Kanpur, India; 3Neuropathology, Chhatrapati Sahuji Maharaj Medical University, Lucknow, India

DTT using FACT Algorithm was performed on 20 normal human fetal brains with age ranging from 16 to 40 weeks of gestational age (GA) to study the normal appearance and development of CC. Quadratic model was considered to examine the trends in callosal FA with increasing GA. A significant positive correlation was observed between callosal bundle FA values and GA. Beyond 19 weeks of GA, CC formed a shape like adult form only in terms of superficial appearance that further showed increment in both fiber length and thickness with age. The ability to noninvasive monitoring of CC development in vivo should greatly improve our understanding of the normal developmental pattern of CC in human fetal brain that may be used as a reference for the diagnosis of developmental defects of the CC.