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Abstract #0493

Quantitative Diffusion Tensor Tractography (DTT) of Motor and Sensory White Matter Pathways in Cerebral Palsy

Richa Trivedi1, Shruti Agarwal2, Vipul Shah3, Vimal K. Paliwal4, Ram K S Rathore2, Rakesh K. Gupta1

1Department of Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 2Department of Mathematics and Statistics, Indian Institute of Technology, Kanpur, India; 3Pediatric Orthopedic Surgery unit, Bhargava Nursing Home, Lucknow, India; 4Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India

DTT using FACT Algorithm was performed on 39 children with cerebral palsy (CP) (8 years mean age) as well as 14 age/ sex matched healthy controls. Free hand ROIs for FA and MD quantitation were drawn on axial T2 image near the brains vertex on the precentral and postcentral gyri, and were defined as motor or sensory tracts, respectively. Based on the present study, it appears that patients with CP with normal imaging on conventional MRI have microstructural damage predominately in the sensory pathway. In conclusion, this quantitative DTT characterizes the trends in spatially averaged diffusivity and FA for the CP patients with normal as well as abnormal imaging in motor and sensory tracts.