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Abstract #0554

Dual Gradient Echo MRI Method for the Evaluation of Muscle Microvascular Function

Otto Alexander Sanchez1, Elizabeth Anne Copenhaver1, Marti Ann Chance1, Michael James Fowler2, Jane Kent-Braun3, Bruce Murray Damon1,4

1Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA; 2Diabetes, Endocrinology, & Metabolic Division, Vanderbilt University, Nashville, TN, USA; 3Kinesiology, University of Massachusetts-Amherst, Amherst, MA, USA; 4Biomedical Engineering, Vanderbilt University, Nashville, TN, USA

To test the ability of a dual GRE MRI method to detect microvascular dysfunction, the time course of SI6 and SI46 , reflecting blood volume and %HbO2, respectively were compared between healthy subjects and individuals at high risk of microvascular disease (type 2 diabetics). Changes in SI between baseline and peak (δSI) and time to peak TTP following isometric contractions of 50%MVC and MVC were compared between groups. Subjects with type 2 diabetes had a higher BMI and HbA1c values than healthy individuals. δSI6 and δSI46 were significantly lower in diabetic subjects following 50%MVC. This method can potentially detect microvascular dysfunction.