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Abstract #0609

Non-Invasive, Whole-Brain CMRO2 Mapping of the Human Brain

Ian C. Atkinson1, Keith R. Thulborn1

1Center for MR Research, University of Illinois at Chicago, Chicago, IL, USA

An MR-based technique for whole-brain CMRO2 mapping is introduced and demonstrated in the human brain. This new approach incorporates a biologically based model of metabolic water production and persistence and accounts for brain tissue mass. Unlike positron emission tomography based CMRO2 approaches, this new technique allows CMRO2 maps to be obtained from humans without radioactive tracers or invasive measurements.