Performance of Hyperpolarized 1,4-13C2 Fumarate in a Murine Lymphoma Model in Vivo, a New Diagnostic Agent for Oncology

Pernille Rose Jensen¹, Rene in 't Zandt¹, Magnus Karlsson¹, Anna Gisselsson¹, Georg Hansson¹, Mathilde Hauge Lerche¹

We have developed hyperpolarized 1,4-¹³C₂ fumarate as a new promising metabolic marker for oncology. Metabolic parameters like up-take and conversion significantly influences imaging parameters like timing and concentration. Here we show a comparison between two substrates, hyperpolarized 1-¹³C pyruvate, which previously has been shown to be an oncology marker1, and the new agent, 1,4-¹³C₂ fumarate. In a mouse EL-4 lymphoma model, the optimal timing and concentration are determined after which the SNR and contrast for the two substrates in the metabolic images are evaluated and compared.