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Abstract #0613

Noninvasive Monitoring of CCl4 Induced Acute and Chronic Liver Damage in Rat by SQ and TQF 23Na MRI

Yong Gao1, Judy James1, Navin Bansal1

1Radiology, Indiana University School of Medicine, Indianapolis, IN, USA

Single-quantum (SQ) and triple-quantum-filtered (TQF) 23Na MRI and shift-reagent- (SR-) aided 23Na and 31P MRS were employed to monitor the progression of liver injury by CCl4 intoxication of rats. Acute high-dose CCl4 (2.5 ml/kg) caused increase in SQ and TQF 23Na MRI signal intensity (SI) due to an increase in intracellular [Na+]. Chronic low-dose CCl4 (0.5 ml/kg twice weekly for 8 weeks) caused an increase in SQ SI due to increased extracellular space, and an increase in TQF SI due to extracellular fibroses. 23Na MRI may prove useful in diagnosis of liver diseases because of its sensitivity to liver injury.