Abstract #0615

Dynamic MRSI for Hyperpolarized [1-13C]-Pyruvate with Multiband Pulses Applied in the TRAMP Prostate Cancer Mouse Model

Peder E. Z. Larson¹, Robert Bok¹, Adam B. Kerr², Albert P. Chen³, Simon Hu¹, Matthew L. Zierhut¹, Michael Lustig², John M. Pauly², Sarah J. Nelson¹, John Kurhanewicz¹, Daniel B. Vigneron¹

¹Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, CA, USA; ²Electrical Engineering, Stanford University, Stanford, CA, USA; ³Global Applied Science Lab, GE Healthcare, Toronto, Ontario, Canada

We have applied a new serial, time-resolved ¹³C MRSI acquisition method for metabolic imaging in the TRansgenic Adenocarcinoma of Mouse Prostate (TRAMP) mouse model in order to investigate the uptake and metabolic dynamics within tumors and in normal tissues following injection of hyperpolarized pyruvate. This new method is based on tailored multiband excitation pulses that preserve the magnetization over time. The prostate tumors have characteristically high lactate conversion and, as this study showed, a characteristic dynamic curve. The results demonstrated significant tumor heterogeneity, with variations in pyruvate perfusion/uptake and lactate conversion.