Abstract #0627

Absolute Cerebral Blood Volume (CBV) Quantification Without Contrast Agents Using Inflow Vascular-Space-Occupancy (IVASO) with Dynamic Subtraction

Manus Joseph Donahue¹, Bradley J. MacIntosh¹, Ediri Sideso², Molly Bright^1,3, James Kennedy², Ashok Handa⁴, Peter Jezzard¹

¹Clinical Neurology, The University of Oxford, Oxford, UK; ²Nuffield Department of Clinical Medicine, The University of Oxford, Oxford, UK; ³Advanced MRI Section, LFMI, NINDS , The National Institutes of Health, Bethesda, MD, USA; ⁴Nuffield Department of Surgery, The University of Oxford, Oxford, UK

A non-invasive approach for quantifying arteriolar cerebral blood volume (aCBV) using inflow vascular-space-occupancy with dynamic subtraction (iVASO-DS) is presented. iVASO-DS employs a null acquisition (arteriolar blood magnetization nulled) interleaved with a control acquisition (arteriolar blood magnetization positive), which are subtracted to yield an aCBV map. aCBV is found to be 2.80.9% in healthy volunteers (n=8), however was significantly (P<0.01) elevated bilaterally in patients with steno-occlusive artery disease (ipsilateral: 4.11.0%; contralateral: 3.81.1%). iVASO-DS should represent a useful, non-invasive complement to hemodynamic imaging protocols for understanding both healthy brain function and hemodynamic impairment in patients with abnormal CBV.