Manus Joseph Donahue1, Bradley J. MacIntosh1, Ediri Sideso2, Molly Bright1,3, James Kennedy2, Ashok Handa4, Peter Jezzard1
1Clinical Neurology, The University of Oxford, Oxford, UK; 2Nuffield Department of Clinical Medicine, The University of Oxford, Oxford, UK; 3Advanced MRI Section, LFMI, NINDS , The National Institutes of Health, Bethesda, MD, USA; 4Nuffield Department of Surgery, The University of Oxford, Oxford, UK
A non-invasive approach for quantifying arteriolar cerebral blood volume (aCBV) using inflow vascular-space-occupancy with dynamic subtraction (iVASO-DS) is presented. iVASO-DS employs a null acquisition (arteriolar blood magnetization nulled) interleaved with a control acquisition (arteriolar blood magnetization positive), which are subtracted to yield an aCBV map. aCBV is found to be 2.80.9% in healthy volunteers (n=8), however was significantly (P<0.01) elevated bilaterally in patients with steno-occlusive artery disease (ipsilateral: 4.11.0%; contralateral: 3.81.1%). iVASO-DS should represent a useful, non-invasive complement to hemodynamic imaging protocols for understanding both healthy brain function and hemodynamic impairment in patients with abnormal CBV.