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Abstract #0626

Multicenter Reproducibility of Continuous, Pulsed and Pseudo-Continuous Arterial Spin Labeling; Can We Use General Reference Values of Cerebral Blood Flow?

Sanna Gevers1, Matthias J.P. van Osch2, Jeroen Hendrikse3, Reinoud P.H. Bokkers3, Dennis A. Kies2, Wouter M. Teeuwisse2, C.B. Majoie1, Aart J. Nederveen1

1Radiology, Academic Medical Center, Amsterdam, Noord Holland, Netherlands; 2Radiology, Leiden University Medical Center, Leiden, Netherlands; 3Radiology, University Medical Center , Utrecht, Netherlands

Arterial spin labeling (ASL) is a non-invasive imaging technique that can be used to measure cerebral perfusion in the diagnosis and evaluation of brain disease. However, the complicated set up of ASL experiments raises the question whether comparable perfusion images would be obtained when scanning the same subject at different imaging sites and whether multicenter reproducibility of ASL allows the use of general reference values of cerebral blood flow. To answer these questions we assessed intra- and multicenter reproducibility of continuous, pseudo-continuous and pulsed ASL in a group of 6 healthy volunteers scanned twice at multiple sites.