Abstract #0657

Selection of Diagnostic Features to Differentiate Between Malignant and Benign Lesions That Presented as Mass Lesions and Non-Mass Type Enhancement on Breast MRI

Ke Nie¹, Dustin Newell¹, Jeon-Hor Chen^1,2, Chieh-Chih Hsu², Hon J. Yu¹, Orhan Nalcioglu¹, Min-Ying Lydia Su¹

¹Tu & Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA, USA; ²Department of Radiology, China Medical University, Taiwan

Diagnostic features to differentiate between malignant and benign lesions presenting as mass and non-mass types were investigated using 116 lesions. The morphology of lesion (shape/margin and enhancement texture) and the enhancement kinetic parameters were obtained, and then a best feature set was selected by artificial neural network for making differential diagnosis. Morphology parameters can diagnose mass type benign and malignant lesions with a high accuracy (AUC=0.87), and adding Ktrans will further improve to 0.90. On the other hand, neither the morphology nor the kinetic parameters analyzed from outlined lesion ROI for non-mass lesions could differentiate between malignant and benign lesions.