Abstract #0706

New Methods for the Quantification of Myocardial Oxygen Consumption with 17O MRI

Kyle Stephan McCommis¹, Xiang He¹, Dana R. Abendschein², Pradeep M. Gupte³, Robert J. Gropler¹, Jie Zheng¹

¹Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA; ²Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA; ³Rockland Technimed Ltd, Airmont, NY, USA

A new MRI method is presented to calculate the myocardial oxygen consumption rate (MVO₂) using ¹⁷O-enriched blood. Initial in vivo study was performed in normal dogs, as well as in one dog with a severe coronary stenosis. A cardiac T_1ρ -weighted imaging sequence was developed to monitor myocardial T_1ρ signals with and without the presence of metabolic H₂¹⁷O water. Various doses of ¹⁷O-blood were injected intravenously, followed by the injection of ¹⁶O-blood. MVO₂ can then be quantified using a simplified model.