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Abstract #0707

High Energy Phosphate Cardiac Energetics Are Abnormal in Primary Biliary Cirrhosis Patients in the Absence of Functional or Anatomical Abnormalities on Structural MRI

Kieren Grant Hollingsworth1, David EJ Jones2, Jessie Pairman2, Katherine Wilton2, Roy Taylor1, Julia Lindsay Newton2, Andrew Mark Blamire1

1Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle, Tyne and Wear, UK; 2Institute of Cellular Medicine, Newcastle University, Newcastle, Tyne and Wear, UK

Primary Biliary Cirrhosis is an autoimmune liver disease affecting females from middle age. A follow-up study of 770 PBC patients studies indicated an increased risk of cardiac-related death. Phosphorus MRS and anatomical imaging for cardiac morphology were acquired to look for cardiac metabolic stress and dysfunction. For 15 PBC patients, the PCr/ATP ratio was significantly reduced compared to age and weight-matched control subjects, but there was no difference in left ventricle morphology, suggesting metabolic stress only. There was no correlation between PCr/ATP ratio, fatigue severity or age, suggesting that cardiac metabolic stress is a systemic feature of the disease.