Michael Schr1,2, AbdEl Monem El-Sharkawy1, Paul A. Bottomley1,3, Robert G. Weiss1,3
1Russel H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; 2Philips Healthcare, Cleveland, OH, USA; 3Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
A new saturation transfer method to measure the pseudo-first-order rate constant kf of the creatine kinase (CK) reaction employing just two fully-relaxed and one short-TR acquisition is presented. This TRIST method is validated by comparison with conventional progressive saturation kf measures in the human calf. It is then combined with 1D chemical shift imaging to obtain the first 3T measures of CK kinetics in the normal human skeletal muscle and heart.