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Abstract #0709

Validity of a 2-D Wave Field Model in MR Elastography of the Liver

Meng Yin1, Kevin J. Glaser1, Jayant A. Talwalkar2, Armando Manduca1, Richard L. Ehman1

1Department of Radiology, Mayo Clinic, Rochester, MN, USA; 2Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, MN, USA

One advantage of liver MRE over biopsy or ultrasound-based transient elastography is its ability to reduce sampling error by measuring liver stiffness in multiple areas of the liver. While full 7-D wave imaging offers valid measurement of stiffness throughout the liver, the 2-D approach may also provide valid results in a significant part of the volume, with a substantially reduced imaging time. This investigation compared these two approaches, validated the key element of the protocol that makes this possible the optimized acoustic driver system can provide a wave propagation geometry that is suitable for reliable 2-D wave imaging.