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Abstract #0710

Vitreal Viscoelasticity Revealed by Motion-Encoded MRI

Marco Piccirelli1,2, Oliver Bergamin2, Klara Landau2, Peter Boesiger1, Roger Luechinger1

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland; 2Department of Ophthalmology, University Hospital, Zurich, Switzerland

The vitreous shear stress can damage the retina and induce visual loss. Up to now, the vitreous viscoelasticity has only been measured ex-vivo. However, the intravitreal membranes may impact on the shear stress. We determined the vitreous deformation properties in-vivo with intact intravitreal membranes, using peak-combination HARP on CSPAMM images. The vitreous viscoelasticity was determined by fitting the deformation with an analytic model. We were able to split the subjects into 4 groups: gel-like, intermediate, liquefied, and polyphasic vitreous. Our results contrasted with ex-vivo data, which do not include the intravitreal membranes.