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Abstract #0722

Gas-Filled Microbubbles as Intravascular R2* Contrast Agent for Liver MRI

April M. Chow1,2, Jerry S. Cheung1,2, Alfred Yu2, Hua Guo1,2, Ed X. Wu1,2

1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China; 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China

Gas-filled microbubbles possess the potential to become a unique MR contrast agent because of their magnetic susceptibility effect, high biocompatibility and unique cavitation and sonoporation properties. In this study, microbubble susceptibility induced changes were investigated using custom-made albumin-coated microbubbles and a commercially available lipid-based clinical ultrasound contrast agent SonoVue in rat livers in vivo with dynamic susceptibility weighted MRI at 7T. The results demonstrate the potential of gas-filled microbubble as an intravascular R2* contrast agent for liver MRI at high field.