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Abstract #0738

Quantification of Neurodegeneration in Amyotrophic Lateral Sclerosis (ALS) Using DTI and Iron Mapping

Christian Langkammer1, Christian Enzinger1, Stefan Quasthoff1, Paula Grafenauer1, Michaela Soellinger1, Franz Fazekas1, Stefan Ropele1

1Department of Neurology, Medical University of Graz, Graz, Austria

The study sought to better characterise disease related brain tissue changes in amyotrophic lateral sclerosis (ALS) using tract based spatial statistics (TBSS) and regional analyses both on DTI and R2* data. The latter served to quantify iron deposition in deep gray and white matter, focussing on changes along the corticospinal tract. R2* measurements appeared to be more sensitive over DTI in detecting tissue abnormalities.